Polygenic Risk Scores
Download lists of variants and weights comprising polygenic risk scores for five complex diseases, as described in:
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
Khera AV, Chaffin M, et al.
Nature Genetics. 2018. doi:10.1038/s41588-018-0183-z
These polygenic risk scores are made freely available to the academic community for research use. Parties interested in using the scores for commercial purposes should contact the Broad Office of Strategic Alliances and Partnering or send an e-mail to: firstname.lastname@example.org.
Download a list of SNPs (.txt file) comprising the polygenic risk score for lifetime risk of atrial fibrillation as developed in this study:
Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation
Weng LC, et al. Circulation. 2017 Nov 12. pii: CIRCULATIONAHA.117.031431. doi: 10.1161/CIRCULATIONAHA.117.031431
Download Summary Statistics
|PubMed ID||Title||Download files||README files|
|Online in JAMA||Association between titin loss-of-function variants and early-onset atrial fibrillation.||Download files||README|
|Online in Circulation||Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery.||Download files||README|
|PMID:30220432||Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure.||Download files||README|
|PMID:30012220||Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.||Download files||README|
|PMID:29892015||Multi-ethnic genome-wide association study for atrial fibrillation.||Download files||README|
|PMID:29748316||Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval.||Download files||README|
|PMID:28794112||Fifteen Genetic Loci Associated With the Electrocardiographic P Wave.||Download files||README|
|PMID:28416818||Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.||Download files||README|
Genetic Association Datasets
The table below lists genetic association datasets incorporated into the Cardiovascular Disease Knowledge Portal. Filter by data type using the menu at the top, or click on the links to see more details about individual sets.