Polygenic Risk Score Variant Weights

Download lists of variants and weights comprising polygenic risk scores for five complex diseases, as described in:

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
Khera AV, Chaffin M, et al.
Nature Genetics. 2018. doi:10.1038/s41588-018-0183-z

Atrial fibrillation (297.3 MB) | Breast cancer (253 KB) | Coronary artery disease (292.9 MB) | Inflammatory bowel disease (305.1 MB) | Type 2 diabetes (305.6 MB)

These polygenic risk scores are made freely available to the academic community for research use. Parties interested in using the scores for commercial purposes should contact the Broad Office of Strategic Alliances and Partnering or send an e-mail to: partnering@broadinstitute.org.

Download Summary Statistics

PubMed IDTitleDownload files
Genetic Association of Albuminuria with Cardiometabolic Disease and Blood PressureUKB.v2.albuminuria.n382500.zip
PMID:30012220Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.Download files

Genetic Association Datasets

The table below lists genetic association datasets incorporated into the Cardiovascular Disease Knowledge Portal. Filter by data type using the menu at the top, or click on the links to see more details about individual sets.

Filter Dataset Table (Click one to start)